Therapeutic Drug Monitoring of Cyclosporine in Transplanted Patients. Possibilities, Controversy, Causes for Failure
نویسندگان
چکیده
Monitoring cyclosporine therapy is required by the narrow therapeutic index, high pharmacokinetic variability, the increased risk of drug interactions CYP 3A4dependent and nephrotoxicity of the substance substance. The controversies raised by clinical practice are the best time of sampling, the analytical methods used and the feasibility of the pharmacokinetic models to estimate the useful concentrations for preventing rejection and nephrotoxicity, and inherent pharmacokinetic drug interactions with concomitant treatments.
منابع مشابه
A Review on Therapeutic Drug Monitoring of Immunosuppressant Drugs
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